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They couldn’t read the source material. The blastema, a sac of stem cells, is a vital component of limb regeneration. But it’s unclear whether and to what extent the animal also calls on reserves of stem cells, the class of undifferentiated cells that organisms maintain to help with healing. Salamander. “The interesting thing about salamanders is that even though they regenerate, they hardly ever get cancer,” Whited said. Salamanders regrow limbs with less drastic cellular changes than previously thought. Yet even before the axolotl genome was mapped, scientists were using other tools to begin to understand regeneration. Watch as this tiger salamander regrows its leg that was bitten off by a dog!Music: http://www.purple-planet.com & https://www.bensound.com/royalty-free-music Among vertebrates, axolotls are unrivalled in their ability to regrow gills, tails, limbs, and other body parts and internal organs. But they still have more questions than answers, and some of those questions have persisted since the first documented observation of these animals’ strange talent more than 250 years ago. Unlike limb regrowth, which rebuilds complex parts from a nub, the remaining part of a liver expands to the size of the missing portion. A flatworm called a planarian can grow back its entire body from a speck of tissue, but it is a very small, simple creature. Elizabeth Preston is the editor of Muse, a science magazine for kids. While rare now in the wild, axolotls used to hatch en masse, and it was a salamander-eat-salamander world. With a fully sequenced genome in hand, scientists hope they are finally poised to learn how axolotls regenerate lost body parts. Salamanders can replace lost limbs, even as adults, a unique train amongst four-legged creatures in the animal world. This article was written by cYw34. Other scientists did take up those investigations, however, and researchers’ salamander of choice became the axolotl. The scientists found two possible models that lead to the formation of a blastemal—one where stem cells sit dormant within the connective tissue and wait for when they are needed and one where mature connective tissue cells respond to the loss of a limb by “de-differentiating” into limb progenitor cells. This fascinates scientists. Cells then migrate to the wound site and form a blob called a blastema. It’s the bud of a new arm. Limb regeneration: Do salamanders hold the key? Reprinted with permission from Quanta Magazine, an editorially independent publication of the Simons Foundation whose mission is to enhance public understanding of science by covering research developments and trends in mathematics and the physical and life sciences. Yet even before the axolotl genome was mapped, scientists were using other tools to begin to understand regeneration. A right shoulder? He also thinks finding out how axolotls rapidly regrow their lungs could help us learn to heal human lungs, which naturally have some regenerative power. Unlike humans, it has the “superpower” of regenerating its limbs, spinal cord, heart, and other organs. Monaghan said his group is already using the new genome sequence as a reference to make genetically engineered salamanders with CRISPR, the revolutionary genome-editing technology that became available only a few years ago. Until a few years ago, Tanaka said, “Those chunks were way too small to bridge the size of these repetitive sequences.” The technology couldn’t reach from one island of information to the next. Perhaps this regrowth is a remnant of regeneration that fails to reach completion. 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